Pilot | Production Scale Oral Thin Film Casting disintegration property is based on the polymers used. The film disintegrates rapidly within seconds in contact with water or saliva, releases the drug in the mouth and promotes gastrointestinal absorption.
Oral thin film can be used to deliver vaccines by quickly dissolving in mouthand in saliva, this delivery system exhibits many advantages not available in current products which include improved patent compliance, improved bioavailability, reduction in the costs associated with storage, distribution, handling and administration.
Complete integration from one source. Mixing Homogenization, Film line packing line.
Web length 490mm. Coating thickness from 40 – 1000 microns wet.
High coating accuracy.
Individual temperature adjustment zones.
Recording of all process related parameters.
Variable speed of base film
Uniform air flow throughout the machine.
Liquid dosing system with peristaltic pump.
Thickness checking or wet & dry film
Product temperatures & film temperature measurement.
Recording of critical process data in 21 CFR part 11 certified software.
Controls by Allen Bradley and 12.1 IPC by touch panel control with trends.
Report on Excel file can be exported to USB to view on computer.
Equipment can be modified to make patch film of desired size and desired web length.
Cutting and sitting line are a part of the complete processing line for oral strips.